Cooling molecules with light.
My thesis was the direct laser cooling of calcium monohydride — taking a molecule and slowing it with nothing but precisely tuned light. That meant owning the whole apparatus: the laser sources, the frequency stabilization, the vacuum, the cryogenics, and the single-photon detection.
When both the previous senior student and the lab postdoc left within months of each other — during the pandemic, in New York City — I rebuilt the entire cooling laser system solo, retuning it from a 1064 nm infrared design to 635 nm visible red to switch the experiment from barium to calcium monohydride. It worked, and it became my first-author paper.